Orca flyer: truly automated NGS library preparation

Orca is a modular automation platform for NGS library preparation with a growing library of ready to run protocols. The flyer shows how it runs the two day SOPHiA GENETICS DNA Prep Kit workflow for 32 samples.

Diagnostic Utility of Low-Pass Whole Genome Sequencing in Prenatal Detection of Chromosomal Abnormalities in an Indian Cohort

Preprint, not peer reviewed. Low-pass whole genome sequencing of 1,508 prenatal samples from India identified chromosomal abnormalities in 168 cases, a diagnostic yield of 11.1%, with aneuploidies making up 71% of the abnormalities detected.

CamSelect NGS technical note: PCR cleanup and size selection

CamSelect NGS is a magnetic bead reagent for DNA cleanup and size selection in NGS and PCR workflows, used at the same bead ratios as AMPure XP. The note compares size selection across bead to sample ratios and shows adapter dimer removal from a library.

NGS Run Planner

Estimates how much sequencing data a run will generate and an approximate cost per sample, based on how efficiently a flow cell is used.

A multimodal lifestyle intervention program targeting the muscle and gut to improve metabolic health among Indian adults with (pre)diabetes: Design of the GUT-DM randomized trial

Describes the design of the GUT-DM randomized trial, which compares standard of care with a 12 week multimodal lifestyle intervention, given with synbiotics or placebo, in Indian adults with (pre)diabetes. Changes in metabolic, physical, mental and gut health will be compared across the three groups.

Manta brochure

Brochure on Manta, the automated DNA/RNA extraction system, and how it helps lab efficiency and consistent results. Fill in a short form to get it.

First functional and taxonomic insights into the microbiome of edible snail, Cipangopaludina lecythis via shotgun metagenomics

Presents the first shotgun metagenomic profile of the edible tissues of the freshwater snail Cipangopaludina lecythis, identifying 38 bacterial phyla dominated by Pseudomonadota. Functional annotation revealed enzymes involved in fatty acid metabolism, energy regulation and chitin metabolism.

De novo plastome assembly of Cymbopogon bhutanicus Noltie, an endemic lemon grass from Bhutan, with geospatial, comparative genomic, and phylogenetic insights

First pathogenomic insights into Ganoderma ellipsoideum as an emerging causal agent of basal stem rot in oil palm

Presents the first draft genome of Ganoderma ellipsoideum (41.6 Mb, 11,939 predicted genes), a newly identified species causing basal stem rot in oil palm in India. The genome reveals a diverse ligninolytic enzyme arsenal and abundant carbohydrate active enzymes linked to plant cell wall degradation.

Segmental duplications and supernumerary chromosomes drive antifungal drug resistance in Candida auris

Combining whole genome sequencing, a copy number variation screen, karyotyping and mutation accumulation analyses in clinical Candida auris isolates, the study finds that small duplications containing ERG11 enhance azole resistance. Large duplications of chromosome 1 form supernumerary chromosomes that reduce susceptibility to caspofungin.

Concordance Between Immunohistochemistry and Sanger Sequencing for IDH1 and IDH2 Mutation Detection in South Indian Adult-type Glioblastoma Patients

Genetic differentiation in Anopheles stephensi from India and Ethiopia: insights from mitochondrial genome analysis

Preprint, not peer reviewed. An analysis of 98 mitochondrial genomes of Anopheles stephensi from India, Pakistan and Ethiopia found high genetic diversity in India and significant differentiation between Indian and Ethiopian populations, suggesting multiple independent introductions into Ethiopia.

White paper: Stability and functional consistency of CamSelect NGS beads

This white paper evaluates CamSelect NGS beads across manufacturing lots, accelerated ageing and simulated international transit. It reports consistent physicochemical properties and reliable DNA recovery and size selection across bead ratios.

Datasheet: Surface characterization of CamSelect NGS magnetic beads

Scanning electron microscopy of the carboxyl magnetic beads in CamSelect NGS shows a predominantly spherical, uniform population between 400 and 700 nm with a tight size distribution. Together with DLS and zeta potential data, this supports consistent separation, binding capacity and automation compatibility.

Datasheet: Magnetic separation performance of CamSelect NGS beads

A study on the SepMag LAB system shows CamSelect NGS beads deliver consistent magnetic separation across independent manufacturing lots. Performance stayed stable after shipping, refrigerated and ambient storage, and accelerated thermal exposure.

MedGenome adopts Beluga by Cambrian Bioworks for scalable whole exome sequencing workflows

Bengaluru, April 11, 2026, Cambrian Bioworks has installed Beluga, its automated sample preparation system, at MedGenome, enabling fully automated high-throughput sequencing workflows.

Cambrian Bioworks Secures Patent for CamSelect Long™ Bead Technology Enabling High Molecular Weight DNA Enrichment for Long-Read Sequencing

Cambrian Bioworks announced that it has been granted a patent for its "Method of Enriching High-Molecular-Weight DNA."

Manta by Cambrian Bioworks earns CE-IVD mark for clinical DNA extraction

Cambrian Bioworks is proud to announce that Manta, its fully automated nucleic acid extraction platform, has received CE-IVD certification under Regulation (EU) 2017/746 (IVDR).

Cambrian Bioworks launches Beluga, an automated liquid handler at Medlab Middle East, UAE

Cambrian Bioworks made its debut at Medlab Middle East in Dubai with the launch of Beluga, an advanced automated liquid handler designed to streamline PCR preparation workflows.

Manta Installed in the FRIGE lab at IHG

Cambrian Bioworks proudly announces the installation of Manta, the nucleic acid automation device, at the Institute of Human Genetics (IHG) within the FRIGE laboratory.

Manta’s Grand Debut at BHU, Varanasi

Varanasi, January 30, 2024, Manta, the nucleic acid automation device from Cambrian Bioworks, made its grand debut in Professor Gyaneshwer Chaubey’s lab at Banaras Hindu University (BHU).

Beluga brochure: walkaway automation for sample preparation

Beluga brings end to end automation to nucleic acid extraction, taking a clinical sample to a PCR ready plate with no manual pipetting, transfers or supervision. The brochure covers its hybrid magnetic rod extraction and liquid handling design, barcode tracking and typical workflows.

Orca brochure: purpose built automation for NGS library preparation

Orca automates NGS library preparation from DNA eluates to sequencing ready libraries, pairing an 8 channel pipette with a single channel pipette in an enclosure fitted with a UV lamp and HEPA filters. The brochure walks through a typical library preparation workflow on the platform.

Magnetic bead solutions for NGS: catalogue

A catalogue of Cambrian magnetic beads for NGS, covering CamSelect NGS for PCR cleanup and size selection, CamSelect Long for long read sequencing and CamSelect Strep for target capture.

Product catalogue 2025-26

Cambrian's catalogue of genomic sample preparation kits and automation tools, organized by research domain from cancer genomics to microbiome research. It brings together the kits and NGS products for each application.

The OncoSeek Bundle: sample preparation for cancer care

The OncoSeek Bundle covers sample preparation for cancer testing, from solid tumors to liquid biopsy. It maps cancer types and common genomic tests to the nucleic acids and sample types they need.

Tuna flyer

Product flyer for Tuna, the walk away magnetic bead mover. Fill in a short form to open the PDF.

Beluga OncoSeek flyer: walkaway automation for cfDNA isolation

Beluga OncoSeek automates cell free DNA isolation for precision oncology, from direct loading of EDTA, Streck, Falcon or microcentrifuge tubes to elution into barcoded storage tubes. Its workflow is built to eliminate genomic DNA contamination for applications such as liquid biopsy and MRD monitoring.

Medusa flyer: automated liquid handling robot

Medusa is a compact automated liquid handler for routine lab workflows such as aliquoting, serial dilution and assay setup. The flyer covers its core capabilities, including sample pooling and cherry picking, and smart features like liquid level and clot detection.

Medusa flyer: automated broth microdilution for AST

Medusa automates plate preparation for broth microdilution antimicrobial susceptibility testing, including antibiotic dilution series, inoculum distribution and panel setup. Smart sensors track each transfer to keep the process accurate and consistent.

Blood RNA Isolation Kit flyer

The Cambrian Blood RNA Isolation Kit uses magnetic bead chemistry for rapid, scalable RNA purification from 0.5 to 2 mL of whole blood. The flyer shows yield across input volumes for applications such as BCR ABL testing and RNA sequencing.

OncoSeek cfDNA Kit flyer

The OncoSeek cfDNA Kit isolates circulating cell free DNA for oncology applications including liquid biopsy and minimal residual disease testing, with elution volumes as low as 30 µL. In a trial across 7 clinical samples it gave higher yields from 1 mL of plasma than a comparison kit using 2 mL.

FFPE DNA Isolation Kit flyer

Cambrian's bead based FFPE gDNA Extraction Kit isolates DNA from challenging FFPE tissue for NGS and PCR on automated equipment. The flyer shows yields and DNA integrity across FFPE samples from several organ sites with tumor content from 10% to 90%.

FFPE RNA Isolation Kit flyer

The Cambrian FFPE RNA Isolation Kit delivers consistent yield and purity from FFPE samples with a 3 hour protocol. The RNA suits gene expression analysis, NGS, qPCR, microarray profiling and biomarker discovery.

Automated workflow solutions for HPV DNA testing

HPV is responsible for over 90% of cervical cancer cases, and early detection can help prevent the disease. The flyer presents Cambrian's total HPV solution on Beluga, from nucleic acid extraction and PCR preparation to report generation.

Multi Sample gDNA Isolation Kit flyer

Cambrian's Multi Sample gDNA Isolation Kit uses CamBeads magnetic bead technology for high throughput genomic DNA isolation from whole blood, tissue and body fluids on automated platforms. It supports genetic testing, HLA typing, newborn screening and NGS workflows.

Stool DNA Isolation Kit flyer

The Cambrian Stool DNA Isolation Kit recovers high molecular weight DNA from complex stool samples for microbiome and metagenomic studies. It uses bead based mechanical lysis and is built to handle the high inhibitor content of stool.

Viral DNA/RNA Isolation Kit flyer

The Cambrian Viral DNA/RNA Kit uses magnetic bead technology on the Manta platform to extract DNA and RNA from plasma, VTM and serum. It runs 1 to 32 samples in about 30 minutes for pathogen detection, viral genotyping, PCR and NGS.

Twist WGS library preparation on Orca

Automate the Twist WGS library preparation workflow on Orca with a standardised, walk away workflow designed for consistent library preparation.

CamSelect Long workflow overview

Workflow overview for CamSelect Long, linked from the CamSelect Long page.

Manta CDSCO IVD certificate

Manta is IVD certified with CDSCO, the Indian regulator for in vitro diagnostic devices.

ISO 13485 certificate

Cambrian holds ISO 13485 certification for quality management in the design and manufacturing of medical devices.

Manta made in India document

Document linked from the Manta page under the note that Manta is designed, tested and manufactured in India.

Beluga CDSCO certificate

CDSCO certificate for Beluga, linked from the Beluga page.

Beluga daily schedule simulator

Map out a viral RNA/DNA workflow on Beluga in advance: structure the day, see how runs are sequenced, and understand expected throughput across batches.

Beluga savings calculator

Estimates cost implications, pricing structure and potential payback of automating with Beluga, from your sample volume and workflow. Marked coming soon on the tools page.

Molecular lab setup planner

Room by room planning guide for an NGS laboratory, with recommended equipment, workflow layouts and contamination control.

Rare diseases, prenatal testing, and the future of genetic screening, Dr. Ashwin Dalal

Dr. Ashwin Dalal, a medical geneticist, talks about rare diseases, prenatal testing, and what is driving and holding back genetic diagnostics in India.

How does microbiome sequencing unlock precision medicine? Kumar Sankaran

Kumar Sankaran, CEO of Leucine Rich, on how gut microbiome sequencing could support disease prediction and personalised treatment.

Smart algorithms, pooled testing, and the future of molecular diagnostics, Dr. Manoj Gopalkrishnan

Dr. Manoj Gopalkrishnan, founder of Algorithmic Biologics, on molecular computing, pooling strategies and molecular testing workflows.

Genomic sequencing in India: where are we and what is next, Dr. Sudha Rao

Dr. Sudha Rao on building one of the first genomic service labs in India and where genomics is heading next.

Managing technical complexities of a high throughput WES lab

Scaling Whole Exome Sequencing (WES) in high-throughput labs is challenging and involves unique caveats. It requires precise workflow optimization, efficient data management, and robust automation to ensure consistent quality.

Shaping the paradigm in male infertility diagnostics

Male infertility remains a complex and underdiagnosed condition, with many genetic causes that are not captured by conventional diagnostic methods like karyotyping or Y-chromosome microdeletion analysis.

Isolating DNA from stool samples for microbiome research

Stool samples are challenging to extract high-quality DNA from due to PCR inhibitors, DNA degradation, and low yields can wreck your sequencing results, but the right extraction method makes all the difference.

Optimizing blood RNA extraction for scalable transcriptomics

RNA extraction is notoriously unpredictable due to factors like sample complexity, operator handling, and workflow sensitivity.

The future of nucleic acid isolation using magnetic beads

Magnetic bead based nucleic acid isolation is transforming sample prep with scalable, automation-compatible workflows.

KFF program file: Blood_FFPE_RNA_CBW

KingFisher Flex program file (.bdz) for blood and FFPE RNA, from the Cambrian protocols page.

KFF program file: KFF_Tissue_Protocol

KingFisher Flex program file (.bdz) for tissue, saliva, stool, plasmid DNA, and FFPE DNA, from the Cambrian protocols page.

KFF program file: KFF_WB_CB_Protocol

KingFisher Flex program file (.bdz) for whole blood, cord blood, and DBS (dried blood spots), from the Cambrian protocols page.

KFF program file: Viral_NA_KFF_CBW_130223

KingFisher Flex program file (.bdz) for viral nucleic acids, from the Cambrian protocols page.

CamSelect NGS protocol

Protocol for the CamSelect NGS, listed under Library preparation reagents on the Cambrian protocols page. Catalog CBWD010.S, CBWD010.75.

Cambrian FFPE gDNA isolation kit protocol

Protocol for the Cambrian FFPE gDNA isolation kit, listed under Automated DNA/RNA extractions on the Cambrian protocols page. Catalog CBWM100.64.

Cambrian Tissue gDNA isolation kit protocol

Protocol for the Cambrian Tissue gDNA isolation kit, listed under Automated DNA/RNA extractions on the Cambrian protocols page. Catalog CBWM096.64.

Cambrian Saliva DNA isolation kit protocol

Protocol for the Cambrian Saliva DNA isolation kit, listed under Automated DNA/RNA extractions on the Cambrian protocols page. Catalog CBWM085.64.

Cambrian Whole Blood gDNA isolation kit protocol

Protocol for the Cambrian Whole Blood gDNA isolation kit, listed under Automated DNA/RNA extractions on the Cambrian protocols page. Catalog CBWM068.64.

Cambrian Whole Blood gDNA isolation kit protocol, SLS

Protocol for the Cambrian Whole Blood gDNA isolation kit, SLS, listed under Automated DNA/RNA extractions on the Cambrian protocols page. Catalog CBWM068.64.SLS.

Cambrian gDNA isolation from whole blood kit for Beluga

Protocol for the Cambrian gDNA isolation from whole blood kit for Beluga, listed under Automated DNA/RNA extractions on the Cambrian protocols page. Catalog CBWM068.64.B.

Cambrian Viral DNA/RNA isolation kit protocol

Protocol for the Cambrian Viral DNA/RNA isolation kit, listed under Automated DNA/RNA extractions on the Cambrian protocols page. Catalog CBWM030.64.

Cambrian Stool DNA isolation kit protocol

Protocol for the Cambrian Stool DNA isolation kit, listed under Automated DNA/RNA extractions on the Cambrian protocols page. Catalog CBWM140.64.

Cambrian Blood RNA isolation kit protocol

Protocol for the Cambrian Blood RNA isolation kit, listed under Automated DNA/RNA extractions on the Cambrian protocols page. Catalog CBWM160.32.

FFPE RNA extraction kit for Manta, protocol

Protocol for the FFPE RNA extraction kit for Manta,, listed under Automated DNA/RNA extractions on the Cambrian protocols page. Catalog CBWM201.32.

Manual FFPE gDNA extraction protocol

Protocol for the Manual FFPE gDNA extraction, listed under Manual DNA/RNA extractions on the Cambrian protocols page. Catalog CBWC100.50, CBWC100.250.

Cambrian DBS gDNA isolation kit protocol

Protocol for the Cambrian DBS gDNA isolation kit, listed under Manual DNA/RNA extractions on the Cambrian protocols page. Catalog CBWC068.DBS250.

Cambrian Multi gDNA isolation kit protocol

Protocol for the Cambrian Multi gDNA isolation kit, listed under Manual DNA/RNA extractions on the Cambrian protocols page. Catalog CBWC040.50, CBWC040.250.

Cambrian Blood RNA extraction kit protocol, manual

Protocol for the Cambrian Blood RNA extraction kit, manual, listed under Manual DNA/RNA extractions on the Cambrian protocols page. Catalog CBWC160.50.

Cambrian Whole blood and Cord blood gDNA isolation kit protocol

Protocol for the Cambrian Whole blood and Cord blood gDNA isolation kit, listed under Manual DNA/RNA extractions on the Cambrian protocols page. Catalog CBWC068.WCB250.

Whole blood and cord blood gDNA extraction on KingFisher Flex

Protocol for the Whole blood and cord blood gDNA extraction on KingFisher Flex, listed under External automation systems on the Cambrian protocols page. Catalog CBWC068.WCB250.

Tissue and amniotic fluid on KingFisher Flex

Protocol for the Tissue and amniotic fluid on KingFisher Flex, listed under External automation systems on the Cambrian protocols page. Catalog CBWC096.250.

Application note: Cleaner & high-yield DNA from whole blood with Manta

Extracting DNA from blood samples is routine, but not always reliable. In clinical and diagnostic labs, inconsistent yields, poor purity, and sample prep complexity can slow down testing and compromise downstream analysis.

Application note download

Download page for a Cambrian application note, behind a short form asking for name, organisation and email.

Blood RNA application note download

Download page for the blood RNA application note, behind a short form asking for name, organisation and email.

Application note: Beluga for traceable NAT workflows

Beluga NAT automates the pre PCR sample preparation steps of nucleic acid testing, such as blood screening and infectious disease panels. The note shows how it reduces manual handling, improves traceability and keeps sample processing consistent.

Application note: Enabling accurate prenatal genetic testing with Beluga

Beluga streamlines cell free DNA sample preparation for non invasive prenatal testing. The note covers loading Streck or centrifuge tubes directly, automated sample and eluate transfers, and barcode scanning from primary tube to 2D barcoded elution tube.

Application note: Error proofing ctDNA extractions for liquid biopsy

Beluga OncoSeek is a fully automated open platform for cell free DNA isolation with end to end barcode traceability. In a trial across 7 clinical patient samples, the OncoSeek ctDNA Kit gave consistently higher yields from 1 mL of plasma than a comparison kit that used 2 mL.

Application note: End to end sample traceability for WES workflows

Beluga brings automation and barcode tracking to whole exome sequencing sample preparation, from primary sample to eluate. The note covers laser etched 2D barcodes, time stamped run records with audit trails, and faster turnaround without mid run interventions.

Application note: Enriching high molecular weight DNA for long read sequencing with CamSelect Long

CamSelect Long is a patented magnetic bead size selection chemistry for enriching high molecular weight DNA. The note looks at whole genome metagenomics from difficult samples such as stool on long read sequencing platforms.

Application note: DNA extraction from dried blood spots

Dried blood spots are an inexpensive way to biobank samples, but the DNA they yield is limited and often degraded. This note describes a protocol using CamBeads paramagnetic beads that works for both manual and automated DNA extraction from DBS cards.

How Strand Life Sciences scaled their whole-exome sequencing throughput by 263% with Manta

Strand Life Sciences handles some of the country’s most demanding genomics workflows across rare disease testing, reproductive health, and oncology.

From manual spin columns to 3,000 DNA extractions in under 4 months

Oneomics operates a molecular genomics laboratory processing a wide range of sample types, including plant tissue, soil, bacterial isolates, animal samples, and occasional human samples for sequencing-based applications.

How Manta helped streamline FFPE DNA Extraction for cancer sequencing

The Advanced Centre for Treatment, Research and Education in Cancer (ACTREC) supports large-scale translational cancer genomics research, working closely with clinicians to study genomic alterations across patient-derived samples.

How Leucine Rich Bio Scaled Gut Microbiome Testing with Manta

Leucine Rich Bio builds gut microbiome testing workflows that convert stool samples into clinically relevant microbial insights through sequencing and downstream microbiome analysis.

How SRM University’s epigenetics lab got cleaner DNA with CamSelect NGS

SRM University is a research-intensive institution with a growing focus on translational biomedical science.

How a growing genomics lab reduced manual extraction complexity

JSS Hospital supports a broad range of research and diagnostic genomics workflows, including whole genome sequencing, transcriptomics, Sanger sequencing, expression studies, microarray, and NGS.

How Drava Life Sciences simplified amplicon purification with CamSelect NGS

Drava Life Sciences is a cancer genetics startup and contract research organisation (CRO) based in Manipal, India.

How Progenics simplified stool DNA cleanup for long-read sequencing with CamSelect NGS

Progenics Labs works at the intersection of microbiology, clinical genomics, and personalised healthcare.

How Biological E standardized viral sample extraction for NGS and qPCR with Manta

Biological E Limited is a Hyderabad-based biopharmaceutical company supporting molecular workflows across viral and cell culture research.

How BioCipher labs standardized nucleic acid extraction across 250 diagnostic panels with Manta

BioCipher Labs is a molecular diagnostics organization operating across multiple centers in India, with labs in Hyderabad, Bangalore, and a growing network of additional sites.

A paradigm shift in male infertility diagnostics: Case study from IHG, Ahmedabad

It is estimated that nearly 1.2 crore men in India may be struggling with infertility, a number that has been steadily rising since the 2000s. Yet, for most, the underlying cause remains undiagnosed.

How Manta has contributed to the growth story of Strand Life Sciences

Strand Life Sciences is a precision medicine company that operates across clinical genomics, oncology, and rare disease diagnostics.

Building Genomics tech in India

Across thousands of healthcare samples every month, labs face delays and inconsistencies. Much of this comes from imported tools that aren’t designed for Indian labs.

How to optimise PCR cleanup for target enrichment panels

Target enrichment panels have become indispensable tools in high-resolution molecular profiling. They are widely used across applications such as oncology, prenatal diagnostics, and pathogen surveillance.

cfDNA is critical for accurate oncology testing. Here’s how to remove genomic DNA contamination from it

Cell-free DNA (cfDNA) carries a wealth of diagnostic information in numerous oncology workflows.

Manta is now an open system. Adapt it to your workflows

‘To enable precision molecular diagnostics’ was our goal when we started building Manta, our automated DNA/RNA extraction device. Every detail, from its design and functionality to the way it’s offered, was shaped by this goal.

The role of input volume in blood RNA extraction

Labs don't always control the volume of blood samples they receive. Pediatric collections, ICU patients, or archived biobank specimens often come with strict volume limitations.

Extracting high-quality RNA for BCR-ABL fusion transcript detection

In 1960, two researchers in Philadelphia spotted a strange anomaly in the blood cells of leukaemia patients. A mysteriously short chromosome that no one had seen before. It would go on to change the course of cancer biology.

RNA degrades fast, here’s how we keep it intact in extractions

When it comes to transcriptomics and gene expression studies, an intact RNA is crucial. But it’s challenging. RNA’s notorious fragility and inherent instability stem from both enzymatic and chemical vulnerabilities.

How RNA became central to modern diagnostics

RNA wasn’t always the molecule to watch. For years, it was seen as too unstable, too messy to work with.

Understanding CE‑IVD and Diagnostic Validation

In the world of diagnostic technologies, symbols on the label are crucial. They’re declarations of safety, intent, and regulatory compliance.

A 30‑second hack that cleaned up our blood DNA preps on Manta

Freshly collected EDTA blood usually cruises through Manta’s Blood DNA cartridges with textbook 260/280 and 260/230 ratios (≈ 1.8 to 2.0).

Avoiding Common Pitfalls in Genomic DNA Extraction for High-Volume Labs

In high-throughput labs, consistency is critical, yet DNA extraction, the bedrock of molecular diagnostics, remains a common source of variability and contamination.

Step-by-Step Guide to Automated Genomic DNA Extraction from Whole Blood Samples Using the Manta

Extracting high-quality genomic DNA from whole blood is the cornerstone of successful molecular diagnostics.

Key Quality Metrics to Assess Genomic DNA Post-Extraction

Evaluating the quality of genomic DNA after extraction is a critical step before initiating downstream applications such as PCR, next-generation sequencing (NGS), or genotyping.

Role of Automation in Standardizing Genomic DNA Extraction Protocols

In molecular diagnostics, the accuracy of the reports begins with DNA extraction. Even the slightest variation in this process can trigger a domino effect of issues: failed PCRs, distorted NGS data, or flawed genetic diagnoses.

5 Common Mistakes While Extracting DNA from Blood for Sequencing Workflows and How to Avoid Them

DNA extraction is the foundation of any sequencing workflow. Yet, even experienced labs can make mistakes that compromise DNA quality, yield, or integrity.

Single-Sample Automated DNA Extraction: How to Do It Without Wasting Reagents

In molecular diagnostics, DNA extraction is the foundation of all subsequent analysis. However, when dealing with a single sample, labs often face the challenge of minimizing reagent waste while maintaining high-quality DNA yields.

How Genomic DNA Extraction Differs for PCR vs. NGS Applications

Extracting high-quality genomic DNA is the foundational step in any molecular biology workflow. However, the downstream application determines the stringency required in both quantity and quality of the extracted DNA.

Principles Behind Genomic DNA Extraction using Manta

In the high-stakes world of clinical diagnostics, DNA and RNA extraction is a critical first step, the foundation on which downstream analyses like PCR, NGS, and sequencing rest.

Genomic DNA Extraction in 2025: What Clinical Labs Need to Know

In 2025, genomic DNA extraction continues to be the foundation of clinical diagnostics. But the landscape is shifting, faster tests, higher sample volumes, and greater sample diversity are now the norm.

Why should labs automate their workflows in 2025?

As molecular testing volumes continue to surge across oncology, infectious disease, and reproductive health, automation is no longer a “nice-to-have.” It’s the backbone of speed, accuracy, and scale.

Achieving High Molecular Weight DNA Extraction from Whole Blood: A Technical Guide for Precision Labs

High Molecular Weight (HMW) DNA, typically defined as DNA fragments greater than 50 kb, is a critical asset for a range of advanced molecular applications like long-read sequencing (PacBio, Oxford Nanopore), genome assembly, and structural variant detection.

5 silent pitfalls that wreck WES sample prep

Whole exome sequencing (WES) is a transformative tool in genomic research and clinical diagnostics, offering a focused view of protein-coding regions of the genome.

How to Minimize DNA Shearing During Blood Extraction for Long-Read Sequencing Applications

Long-read sequencing platforms such as PacBio Single Molecule Real-Time (SMRT) sequencing and Oxford Nanopore Technologies (ONT) have transformed genomics by providing unprecedented read lengths, enabling the resolution of complex genomic regions…

Preventing Hemolysis in Automated Blood DNA Extraction

Hemolysis, the rupture of RBCs, releases hemoglobin into the sample, which can contaminate DNA preparations, inhibit downstream enzymatic reactions, and reduce overall DNA quality.

Troubleshooting Low DNA Yield from Blood Samples: A Guide for Clinical Labs

When a molecular assay fails, DNA yield is often the first suspect. Yet what counts as “low yield” isn’t always obvious.

Unlock pure stool DNA for microbiome sequencing

The gut microbiome is a bustling ecosystem of bacteria, fungi, and other microbes that play a crucial role in everything from digestion to immune function.

UTI Diagnostics: Current Methods and Advancements

The global UTI diagnostics market surges past $4 billion annually, driven by rising infection rates and an aging population. Yet a stark reality persists: millions still rely on decades-old testing methods that take days to deliver results.

AI in digital pathology

The story of pathology unfolds across three revolutionary waves. In the 19th century, the microscope transformed medicine by revealing the cellular universe, establishing the foundation of modern pathology.

The tech behind WholeSlide Imaging

Picture a traditional microscope transformed into a high-tech powerhouse.

A revolution in pathology

When you visit your doctor with concerning symptoms, they begin their investigation. Blood tests might tell part of the story, but sometimes it’s not enough. That's when radiology steps in, MRI and CT scans reveal a bigger picture.

AI, Rapid PCR, and the Future of Drug-Resistant TB Detection

Tuberculosis stalks humanity like a persistent shadow. Each year, nearly 10 million people contract TB, with over 1.5 million succumbing to the disease.

The Role of Multiplex PCR Panels in Infectious Disease Diagnostics

PCR panels have revolutionized the field of infectious disease diagnostics. Multiplex PCR panels utilize multiple sets of primers to amplify several target sequences in one reaction.

Selecting Biomarkers in Pharmacogenetics

The heart of pharmacogenetics lies in biomarkers molecular indicators that reveal how individuals metabolize, respond to, or tolerate specific drugs.

Precision in lung cancer treatment with pharmacogenetics

Lung cancer, one of the deadliest cancers globally, demands precision in treatment. Every patient’s journey is different what works for one may fail for another.

The Role of NIPT in Early Detection of Rare Genetic Disorders

Non-invasive prenatal testing (NIPT) has already made a profound impact on prenatal care, offering a safer, more accurate alternative to invasive procedures like amniocentesis.

Hospital Surveillance for AMR

Antimicrobial resistance (AMR) is one of the most urgent global health threats, with projections suggesting that it could cause 10 million deaths annually by 2050 if left unchecked.

Understanding cervical cancer and the power of early detection

Cervical cancer kills over 300,000 women annually, striking hardest in low- and middle-income countries. Cervical cancer originates in the cells lining the cervix.

Diagnosis of Bloodstream Infections: Current methods and emerging technologies

Bloodstream infections (BSIs) affect millions of people each year, and diagnosing them is challenging, mainly because symptoms like fever and fatigue are non-specific and overlap with many other conditions.

Biobanks need a better system to store DNA samples

Back in 2009, TIME magazine featured biobanks among “10 Ideas Changing the World Right Now”.