Purpose-built automation for NGS library preparation

Purpose-built automation for NGS library preparation

Purpose-built automation for NGS library preparation

Purpose-built automation for NGS library preparation

Run validated workflows from Twist, IDT, Illumina, NEB, and SOPHiA GENETICS (or automate your own with our AI-powered protocol builder). Orca delivers precise, reproducible liquid handling to standardize library preparation across every run.

Run validated workflows from Twist, IDT, Illumina, NEB, and SOPHiA GENETICS (or automate your own with our AI-powered protocol builder). Orca delivers precise, reproducible liquid handling to standardize library preparation across every run.

Inside Orca

Engineered for precision

Orca integrates all the essential modules for efficient library preparation. It combines an on-deck fluorometer, temperature-controlled reagent modules, and precise liquid handling to deliver consistent libraries.

Orca deck with numbered modules

01

Elevated pipette tip racks

02

On-deck thermal cycler

03

96-well plate positions

04

Reagent reservoir

05

Quantification module

06

Peltier module for reaction plate

07

Hybrid Peltier module

08

Magnetic shaker module

Pre-validated protocols

Run them right out of the box

Orca comes with a growing library of pre-validated workflows for leading NGS library preparation kits from Twist, IDT, Illumina, NEB, SOPHiA GENETICS, and other trusted providers. Pick one, load the deck, and press run - no method development required.

  • DNA & RNA library prep for short- and long-read platforms

  • Hybridization capture & target enrichment

  • Locked parameters and audit trail for reproducible results

  • New England Biolabs
    New England Biolabs
    New England Biolabs

Disclaimer: All product names, logos, and trademarks shown are the property of their respective owners. Their use does not imply endorsement, affiliation, or partnership with Cambrian Bioworks unless expressly stated.

Walk-away workflow

How Orca works

Orca delivers high-quality libraries with an easy-to-set-up workflow. Real-time run visibility keeps your team informed without needing to stay at the instrument.

Load the deck

Load the deck

Load the deck

Load the deck

Pick a protocol

Pick a protocol

Pick a protocol

Pick a protocol

Press run

Press run

Press run

Press run

Monitor remotely

Monitor remotely

Monitor remotely

Monitor remotely

AI Protocol Builder

Build AI-powered protocols with Reef

Upload a kit's IFU, and Reef, Orca's AI protocol builder, automatically converts them into a deck-aware automation workflow. Review and validate every step before running the protocol on the instrument.

Powered by Seahorse

Powered by Seahorse

Powered by Seahorse

Powered by Seahorse

Seahorse is the software platform behind Orca, designed to simplify sequencing operations from sample intake to analysis. It manages run planning, sample tracking, LIMS integration, and downstream analysis through a single, connected workflow.

Seahorse is the software platform behind Orca, designed to simplify sequencing operations from sample intake to analysis. It manages run planning, sample tracking, LIMS integration, and downstream analysis through a single, connected workflow.

Seahorse is the software platform behind Orca, designed to simplify sequencing operations from sample intake to analysis. It manages run planning, sample tracking, LIMS integration, and downstream analysis through a single, connected workflow.

Seahorse is the software platform behind Orca, designed to simplify sequencing operations from sample intake to analysis. It manages run planning, sample tracking, LIMS integration, and downstream analysis through a single, connected workflow.

Smart run planning

Smart run planning

Smart run planning

Smart run planning

Automatically schedules runs to maximize instrument utilization, minimize reagent waste, and reduce turnaround time.

Automatically schedules runs to maximize instrument utilization, minimize reagent waste, and reduce turnaround time.

Cross-panel batching

Cross-panel batching

Cross-panel batching

Cross-panel batching

Process multiple assay panels in a single Orca run by sharing common library preparation steps and performing target enrichment in parallel.

Process multiple assay panels in a single Orca run by sharing common library preparation steps and performing target enrichment in parallel.

LIMS connectivity

LIMS connectivity

LIMS connectivity

LIMS connectivity

Seamlessly exchanges sample information, manifests, and runs data with your existing LIMS for uninterrupted laboratory workflows.

Seamlessly exchanges sample information, manifests, and runs data with your existing LIMS for uninterrupted laboratory workflows.

Pipeline management

Pipeline management

Pipeline management

Pipeline management

Automatically triggers secondary and tertiary analysis and tracks every sample through to final report generation.

Automatically triggers secondary and tertiary analysis and tracks every sample through to final report generation.

Why labs choose Orca

Orca V/S Hamilton Clinical NGS STARlet

Orca V/S Beckman Coulter Biomek i7

Orca V/S Tecan Fluent 480

Orca V/S Opentrons OT-2

Orca V/S Agilent Bravo

Orca V/S SPT Labtech Firefly

Features

Orca

Hamilton Clinical NGS STARlet

Throughput

8–24 samples/run

24 samples/run

Deck capacity

9 positions

25 positions

In-built on-deck thermocycler

Yes

Yes

Combined magnetic shaker module

Yes

No, add-on module

Onboard fluorometer

Yes

No

In-built on-deck heater module

Yes

Yes

Standalone operation

Yes

No

In-built UV/HEPA

Yes

No, optional UV

AI-assisted protocol onboarding & customization

Yes (in-built AI protocol builder)

No

Open system

Open

Open

LIMS connectivity

Yes

Yes, LIS/LIMS integration

Integrated smart run planning

Yes

No

Pipeline management

Yes

No

Footprint

100 × 85 × 90 cm

112.5 × 79.5 × 90.3 cm

Orca V/S Hamilton Clinical NGS STARlet

Orca V/S Beckman Coulter Biomek i7

Orca V/S Tecan Fluent 480

Orca V/S Opentrons OT-2

Orca V/S Agilent Bravo

Orca V/S SPT Labtech Firefly

Features

Orca

Hamilton Clinical NGS STARlet

Throughput

8–24 samples/run

24 samples/run

Deck capacity

9 positions

25 positions

In-built on-deck thermocycler

Yes

Yes

Combined magnetic shaker module

Yes

No, add-on module

Onboard fluorometer

Yes

No

In-built on-deck heater module

Yes

Yes

Standalone operation

Yes

No

In-built UV/HEPA

Yes

No, optional UV

AI-assisted protocol onboarding & customization

Yes (in-built AI protocol builder)

No

Open system

Open

Open

LIMS connectivity

Yes

Yes, LIS/LIMS integration

Integrated smart run planning

Yes

No

Pipeline management

Yes

No

Footprint

100 × 85 × 90 cm

112.5 × 79.5 × 90.3 cm

Orca V/S Hamilton Clinical NGS STARlet

Orca V/S Beckman Coulter Biomek i7

Orca V/S Tecan Fluent 480

Orca V/S Opentrons OT-2

Orca V/S Agilent Bravo

Orca V/S SPT Labtech Firefly

Features

Orca

Hamilton Clinical NGS STARlet

Throughput

8–24 samples/run

24 samples/run

Deck capacity

9 positions

25 positions

In-built on-deck thermocycler

Yes

Yes

Combined magnetic shaker module

Yes

No, add-on module

Onboard fluorometer

Yes

No

In-built on-deck heater module

Yes

Yes

Standalone operation

Yes

No

In-built UV/HEPA

Yes

No, optional UV

AI-assisted protocol onboarding & customization

Yes (in-built AI protocol builder)

No

Open system

Open

Open

LIMS connectivity

Yes

Yes, LIS/LIMS integration

Integrated smart run planning

Yes

No

Pipeline management

Yes

No

Footprint

100 × 85 × 90 cm

112.5 × 79.5 × 90.3 cm

Orca V/S Hamilton Clinical NGS STARlet

Orca V/S Beckman Coulter Biomek i7

Orca V/S Tecan Fluent 480

Orca V/S Opentrons OT-2

Orca V/S Agilent Bravo

Orca V/S SPT Labtech Firefly

Features

Orca

Hamilton Clinical NGS STARlet

Throughput

8–24 samples/run

24 samples/run

Deck capacity

9 positions

25 positions

In-built on-deck thermocycler

Yes

Yes

Combined magnetic shaker module

Yes

No, add-on module

Onboard fluorometer

Yes

No

In-built on-deck heater module

Yes

Yes

Standalone operation

Yes

No

In-built UV/HEPA

Yes

No, optional UV

AI-assisted protocol onboarding & customization

Yes (in-built AI protocol builder)

No

Open system

Open

Open

LIMS connectivity

Yes

Yes, LIS/LIMS integration

Integrated smart run planning

Yes

No

Pipeline management

Yes

No

Footprint

100 × 85 × 90 cm

112.5 × 79.5 × 90.3 cm

Technical specifications

Technical specifications

Technical specifications

Technical specifications

Resources

Resources

Resources

Resources

Bring walk-away library prep to your lab

Schedule a demo with us and see how Orca can make NGS library prep workflows more efficient.